Nicholas O. Burton

Bacterial metabolites alter the consequences of reduced insulin signaling in C. elegans via increasing the expression of the acid sphingomyelinase asm-3.

This study shows that bacterial metabolites affect insulin signaling in C. elegans by altering acid sphingomyelinase expression.

Bacterial-derived cyclic lipopeptides suppress dauer arrest in C. elegans

This study identifies Massetolide F, a bacterial cyclic lipopeptide, as a molecule that suppresses dauer arrest in C. elegans by inducing acid sphingomyelinase expression.

The Caenorhabditis elegans bacterial microbiome influences microsporidia infection through nutrient limitation and inhibiting parasite invasion

The paper shows that certain bacteria reduce microsporidia infection in C. elegans by altering host metabolism and producing inhibitory compounds.

Oocyte mitochondria link maternal environment to offspring phenotype

The paper identifies a role for oocyte mitochondrial electron transport chain remodeling in linking maternal environment to offspring metabolism and survival.

Parental dietary vitamin B12 causes intergenerational growth acceleration and protects offspring from pathogenic microsporidia and bacteria

This study shows that parental vitamin B12 exposure in C. elegans leads to intergenerational growth acceleration and pathogen tolerance in offspring.

A noncanonical polyamine from bacteria antagonizes animal mitochondrial function

This study identifies N1-APA, a noncanonical polyamine produced by bacteria, as a bioactive metabolite that antagonizes animal mitochondrial function and macrophage activation.

Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function

The paper identifies mutations in E3 ubiquitin ligases that restore development in SWI/SNF mutants in C. elegans, suggesting potential therapeutic targets for human developmental disorders.

Opposing steroid signals modulate protein homeostasis through deep changes in fat metabolism in Caenorhabditis elegans

The paper shows that UNC-1 in C. elegans neurons modulates protein homeostasis by altering fat metabolism through neurohormonal signaling involving NHR-1 and DAF-12.

Intergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs

The paper investigates intergenerational stress adaptations in C. elegans across four stress types, finding conserved physiological responses with trade-offs, but no long-term transgenerational gene expression changes.

C. elegans heritably adapts to P. vranovensis infection via a mechanism that requires the cysteine synthases cysl-1 and cysl-2

The paper shows that parental exposure to P. vranovensis increases offspring survival through upregulation of CYSL-1, CYSL-2, and RHY-1.

Neurohormonal signalling controls insulin sensitivity and specificity in C. elegans

The paper investigates how neurohormonal signalling via SSU-1 regulates insulin sensitivity and specificity in C. elegans under different environmental stresses.