Yana Safonova

The paper shows that avian immunoglobulin loci use gene conversion instead of V(D)J recombination, with rapid evolution of inversions that generate pseudogenes as donors for antibody diversity.

The paper identifies a disrupted CCR5-like immunoglobulin gene in black-footed ferrets linked to increased susceptibility to plague caused by Yersinia pestis.

This study vaccinates nonhuman primates with SARS-CoV-2 and MERS-CoV spike proteins to elicit cross-reactive antibodies that neutralize both sarbecoviruses and merbecoviruses.

This paper presents a telomere-to-telomere genome assembly of bighorn sheep, revealing immune gene differences that may explain their susceptibility to respiratory pathogens.

The paper compares IG/TR loci across 44 mammalian species, finding correlations in gene counts, structural patterns linked to population bottlenecks, and haplotype diversity suggesting limited recombination potential.

The paper presents haplotype-resolved genomes of six ape species with high accuracy and provides comparative analyses to study evolutionary diversity and gene family evolution.

IGLoo improves the analysis of immunoglobulin heavy chain locus assemblies in lymphoblastoid cell lines by characterizing somatic recombination events and enhancing germline assembly quality.

The paper evaluates long-read genome assemblies of immunoglobulin loci across 74 vertebrates, identifies assembly errors, and demonstrates methods to correct them using a new pipeline called CloseRead.

The paper shows that genetic variation in the immunoglobulin heavy chain locus influences the diversity and characteristics of the human antibody repertoire.