WNK kinase regulates plasma membrane levels of the WNT inhibitor RNF43
Gabriele Colozza, Ingrid Jordens, Eric Sosa, Jeongmin Ha, Sam B. Wu, Katherina Tavernini, Andrea Català-Bordes, Fiona Farnhammer, Noelia Urbán, Madelon M. Maurice, Bon‐Kyoung Koo
This study identifies WNK kinases as regulators of RNF43, showing they control RNF43 membrane levels and WNT signaling, with implications for cancer therapy.
bioRxiv · Oct 8, 2025 · PreprintBiochemistry