Paweł Borowicz

Intrinsically disordered insert from SH2D2A rewires CD19 CAR signaling via Tyr290

This study identifies a specific tyrosine residue in an intrinsically disordered SH2D2A sequence that rewires CD19 CAR signaling and surface expression.

Identification of DOK2 and PTPN11 as novel interactors of T cell specific adapter protein TSAd

This study identifies DOK2 and PTPN11 as novel interactors of TSAd using AP-MS, revealing their role in negative T cell signaling.

A bioinformatic workflow to facilitate the study of less-understood proteins: the case of SH2D2A

The paper develops a bioinformatic workflow to identify functional roles of less-understood proteins by analyzing scRNA-seq data, applying it to SH2D2A and linking it to T-T synapses enriched for ITGB2.

SH2D2A is an indicator of favourable prognosis in bladder cancer and is enriched in Treg cells

The paper identifies SH2D2A as a favourable prognosis marker in bladder cancer, enriched in Treg cells, and suggests its role in immunotherapy targets.