Author

Hanna Chan

University of OsloORCID 0000-0002-7822-8262Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Brian C. GilmouriD· 3 shared Pawel P. BorowicziD· 3 shared Spurkland AnneiD· 3 shared Santosh PhuyaliD· 2 shared Tuula A. NymaniD· 2 shared Aliki Popidou· 1 shared Andreas LossiusiD· 1 shared Gustavo Antonio de SouzaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

Brian C. GilmourORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Intrinsically disordered insert from SH2D2A rewires CD19 CAR signaling via Tyr290

Pawel P. Borowicz, Brian C. Gilmour, Hanna Chan, Ramakrishna Prabhu Gopalakrishnan, Timo Peters, René Platzer, Jacqueline Seigner, Johan Georg Visser, Hanna Kjelstrup, Aliki Popidou, Manal el Darwich, Ivan Abbedissen, Sebastian L. Andree, Stian Foss, Gustavo Antonio de Souza, , Spurkland Anne

This study identifies a specific tyrosine residue in an intrinsically disordered SH2D2A sequence that rewires CD19 CAR signaling and surface expression.

bioRxiv · Feb 5, 2026 · PreprintImmunology

Identification of DOK2 and PTPN11 as novel interactors of T cell specific adapter protein TSAd

Hanna Chan, Pawel Borowicz, Brian C. Gilmour, Maria Stensland, Ivan Garcia-Loza, Santosh Phuyal, Romina Marone, Lukas T. Jeker, Tuula A. Nyman, Anne Spurkland

This study identifies DOK2 and PTPN11 as novel interactors of TSAd using AP-MS, revealing their role in negative T cell signaling.

bioRxiv · Feb 11, 2025 · PreprintImmunology

A bioinformatic workflow to facilitate the study of less-understood proteins: the case of SH2D2A

Brian C. Gilmour, Hanna Chan, Sachin Kumar Singh, Tuula A. Nyman, Andreas Lossius, Paweł Borowicz, Santosh Phuyal, Anne Spurkland

The paper develops a bioinformatic workflow to identify functional roles of less-understood proteins by analyzing scRNA-seq data, applying it to SH2D2A and linking it to T-T synapses enriched for ITGB2.

bioRxiv · Feb 11, 2025 · PreprintMolecular Biology