Brian C. Gilmour

This study identifies a specific tyrosine residue in an intrinsically disordered SH2D2A sequence that rewires CD19 CAR signaling and surface expression.

This study identifies DOK2 and PTPN11 as novel interactors of TSAd using AP-MS, revealing their role in negative T cell signaling.

The paper develops a bioinformatic workflow to identify functional roles of less-understood proteins by analyzing scRNA-seq data, applying it to SH2D2A and linking it to T-T synapses enriched for ITGB2.

The paper identifies SH2D2A as a favourable prognosis marker in bladder cancer, enriched in Treg cells, and suggests its role in immunotherapy targets.