Author

Karl B. Shpargel

University of North Carolina at Chapel HillORCID 0000-0002-9658-456XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Andrew N Wyper· 2 shared Dimitrios V. BikasiD· 2 shared Gabrielle QuickstadiD· 2 shared Sara Vardabasso· 2 shared Terry MagnusoniD· 2 shared Anthony BeucheriD· 1 shared Ashlyn A. BuzzelliiD· 1 shared Caitlyn L. H. Pham· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersGenetics

Andrew N Wyper

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4 papers

Recent·Most cited

GeneticsBone ResearchPeer-reviewedOct 27, 2026

KMT2C and KMT2D regulate skeletal development through stage-specific epigenetic control of chondrogenesis

Gabrielle Quickstad, Dimitrios V. Bikas, Marielle L. Bond…·Karl B. Shpargel

This study shows that KMT2C and KMT2D regulate skeletal development through epigenetic control of chondrogenesis, with redundancy in their function during bone formation.

DOI 10.1038/s41413-026-00584-8

mouseDNA methylation

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Developmental BiologyJournal of Bone and Mineral ResearchPeer-reviewedDec 19, 2025

A RUNX2 GFP reporter is expressed prior to osteochondral differentiation and models Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly (MDMHB)

Dimitrios V. Bikas, Sara Vardabasso, Gabrielle Quickstad…·Karl B. Shpargel

The paper develops a RUNX2 GFP reporter mouse model to study RUNX2 function in craniofacial development and models the human disorder MDMHB caused by RUNX2 overactivity.

1 citation

mouseprotein structure

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ImmunologyJournal of Clinical InvestigationPeer-reviewedDec 16, 2025

UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes

Ho-Chung Chen, Madison F. Bang, Hsing‐Hui Wang…·Maureen A. Su

This study identifies UTX's role in regulating progenitor CD8+ T cell fate in T1D by interacting with TCF1 and STAT3, showing its importance in autoimmune diabetes progression.

1 citation

mouseexperimental assay

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GenomicsThe EMBO JournalPeer-reviewedMar 10, 2020

HNF1A recruits UTX to activate a differentiation program that suppresses pancreatic cancer

Mark Kalisz, Edgar Bernardo, Anthony Beucher…·Jorge P. Ferrer

This study shows HNF1A recruits UTX to activate a differentiation program that suppresses pancreatic cancer by remodeling enhancers and inhibiting oncogenic pathways.

77 citationstop 5%

mouseexperimental assay

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