Terry Magnuson

KMT2C and KMT2D regulate skeletal development through stage-specific epigenetic control of chondrogenesis

This study shows that KMT2C and KMT2D regulate skeletal development through epigenetic control of chondrogenesis, with redundancy in their function during bone formation.

Timing of standard chow exposure determines the variability of mouse phenotypic outcomes and gut microbiota profile

This study shows that lifetime exposure to different chow diets significantly affects mouse phenotypes and gut microbiota, while developmental exposure reduces variability.

ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse

This study shows ARID1A is essential for silencing sex-linked genes during male meiosis by regulating H3.3 localization and DNA repair.

INO80 regulates chromatin accessibility to facilitate suppression of sex-linked gene expression during mouse spermatogenesis

This study shows INO80 regulates chromatin accessibility and DNA repair factor localization to suppress sex-linked gene expression during mouse spermatogenesis.

The Updated Mouse Universal Genotyping Array Bioinformatic Pipeline Improves Genetic QC in Laboratory Mice

The paper updates the MiniMUGA genotyping array's bioinformatic pipeline to enhance genetic QC in laboratory mice by improving marker annotation, consensus genotypes, and report usability.

RBBP4 modulates gene activity through acetylation and methylation of histone H3 lysine 27

This study investigates how RBBP4 modulates histone H3K27 methylation and acetylation, showing its role in PRC2 function and transcriptional changes in mouse embryonic stem cells.

Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research

The paper introduces MiniMUGA, a genotyping array for mouse genetic QC, showing it effectively discriminates strains, detects genetic constructs, and identifies sex chromosome abnormalities.

HNF1A recruits UTX to activate a differentiation program that suppresses pancreatic cancer

This study shows HNF1A recruits UTX to activate a differentiation program that suppresses pancreatic cancer by remodeling enhancers and inhibiting oncogenic pathways.

Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germ line transcription in the mouse

The paper shows BRG1 interacts with SCML2 to regulate transcription during spermatogenesis, highlighting a novel SWI/SNF-PRC1 co-operation mechanism.

Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits

The paper investigates how the loss of BRG1 or BRM affects chromatin occupancy and transcription, showing cooperative and antagonistic interactions between the two ATPase subunits.