Intranasal gene therapy to prevent infection by SARS-CoV-2 variants
Joshua J. Sims, Jenny A. Greig, Kristofer T. Michalson, Sharon Lian, R. Alexander Martino, Rosemary Meggersee, Kevin B. Turner, Kalyani Nambiar, Cecilia Dyer, Christian J. Hinderer, Makoto Horiuchi, Hanying Yan, Xin Huang, Shu‐Jen Chen, James M. Wilson
This paper demonstrates an intranasal gene therapy approach using an affinity-matured ACE2 decoy protein to prevent SARS-CoV-2 infection and its variants in animal models.
PLoS Pathogens · Jul 15, 2021Peer-reviewedGenetics