Author

Joshua J. Sims

University of PennsylvaniaORCID 0000-0003-4145-5223Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

James M. WilsoniD· 2 shared Rosemary Meggersee· 2 shared Sharon Lian· 2 shared Aradhana KasimsettyiD· 1 shared Cecilia DyeriD· 1 shared Christian J. Hinderer· 1 shared Hanying YaniD· 1 shared Jenny A. Greig· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

James M. WilsonORCID

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2 papers

Recent·Most cited

Molecular BiologyPLoS ONEPeer-reviewedAug 25, 2022

High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronaviruses

Joshua J. Sims, Sharon Lian, Rosemary Meggersee…·James M. Wilson

This paper evaluates an ACE2 decoy inhibitor that remains effective against SARS-CoV-2 variants including Omicron BA.1 and BA.2, and shows broad activity against related sarbecoviruses.

11 citations

humanexperimental assay

𝕏 PostBluesky

GeneticsPLoS PathogensPeer-reviewedJul 15, 2021

Intranasal gene therapy to prevent infection by SARS-CoV-2 variants

Joshua J. Sims, Jenny A. Greig, Kristofer T. Michalson…·James M. Wilson

This paper demonstrates an intranasal gene therapy approach using an affinity-matured ACE2 decoy protein to prevent SARS-CoV-2 infection and its variants in animal models.

46 citations

mousenon-human primate

𝕏 PostBluesky