Author

Sharon Lian

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

James M. WilsoniD· 2 shared Joshua J. SimsiD· 2 shared Rosemary Meggersee· 2 shared Aradhana KasimsettyiD· 1 shared Cecilia DyeriD· 1 shared Christian J. Hinderer· 1 shared Hanying YaniD· 1 shared Jenny A. Greig· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

James M. WilsonORCID

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2 papers

Recent·Most cited

High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronaviruses

Joshua J. Sims, Sharon Lian, Rosemary Meggersee, Aradhana Kasimsetty, James M. Wilson

This paper evaluates an ACE2 decoy inhibitor that remains effective against SARS-CoV-2 variants including Omicron BA.1 and BA.2, and shows broad activity against related sarbecoviruses.

PLoS ONE · Aug 25, 2022Peer-reviewedMolecular Biology

Intranasal gene therapy to prevent infection by SARS-CoV-2 variants

Joshua J. Sims, Jenny A. Greig, Kristofer T. Michalson, Sharon Lian, R. Alexander Martino, Rosemary Meggersee, Kevin B. Turner, Kalyani Nambiar, Cecilia Dyer, Christian J. Hinderer, Makoto Horiuchi, Hanying Yan, Xin Huang, Shu‐Jen Chen, James M. Wilson

This paper demonstrates an intranasal gene therapy approach using an affinity-matured ACE2 decoy protein to prevent SARS-CoV-2 infection and its variants in animal models.

PLoS Pathogens · Jul 15, 2021Peer-reviewedGenetics