Author

Chuxuan Li

Rice UniversityORCID 0000-0001-9386-9909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Yang GaoiD· 2 shared Aanya Gupta· 1 shared Abhinav K. JainiD· 1 shared Antonello MaiiD· 1 shared Barry J. GrantiD· 1 shared Bigang Liu· 1 shared Bjoern PetersiD· 1 shared Brendan Ha· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

Yang GaoORCID

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Author profile →

3 papers

Recent·Most cited

An Open Benchmark for Systems Vaccinology: Insights from the CMI-PB Challenges

Pramod S. Shinde, Lisa Willemsen, Jiyeun Lee, Shelby Orfield, Ziyuan Ren, Minori Aoki, Nicola Thrupp, Aanya Gupta, Cheng-Chang Wu, Liran Mao, Chuxuan Li, Yuhao Tan, Tram Anh Nguyen, Nou Chang, Philipp S. L. Schäfer, , Bjoern Peters

The paper benchmarks computational models predicting B. pertussis booster vaccine responses using multi-omics data from three cohorts, identifying key predictors of immunity and establishing a community resource for systems vaccinology.

bioRxiv · Aug 28, 2026 · PreprintImmunology

Structural Activation of DNA Unwinding by MCM8/9/HROB

Chuxuan Li, Colin To, Temitope M Adeleke, David R. McKinzey, Yang Gao, Michael A. Trakselis

This study presents dynamic structures of MCM8/9 with DNA, HROB, and ATP analogs to elucidate the mechanism of MCM8/9 DNA unwinding and activation by HROB.

bioRxiv · Jun 23, 2026 · PreprintBiochemistry

Quinoline-based compounds can inhibit diverse enzymes that act on DNA

Jujun Zhou, Qin Chen, Ren Ren, Jie Yang, Bigang Liu, John R. Horton, Caleb Chang, Chuxuan Li, Leora Maksoud, Yifei Yang, Dante Rotili, Abhinav K. Jain, Xing Zhang, Robert Blumenthal, Taiping Chen, , Xiaodong Cheng

This study identifies quinoline-based compounds that inhibit DNA methyltransferases and other DNA-targeting enzymes, with compound 11 inducing DNA damage response in cancer cells.

Cell chemical biology · Oct 21, 2024Peer-reviewedMolecular Biology