Nicola Thrupp

Multimodal profiling and intersectional genetics reveal CA1 border inhibitory neuron diversity and postnatal emergence of retrosplenial connectivity

The paper identifies molecular and developmental diversity in CA1 border inhibitory neurons and shows their postnatal emergence of retrosplenial connectivity.

An Open Benchmark for Systems Vaccinology: Insights from the CMI-PB Challenges

The paper benchmarks computational models predicting B. pertussis booster vaccine responses using multi-omics data from three cohorts, identifying key predictors of immunity and establishing a community resource for systems vaccinology.

Putting computational models of immunity to the test - an invited challenge to predict B. pertussis vaccination outcomes

The paper benchmarks 49 algorithms for predicting B. pertussis vaccination outcomes, finding that purpose-built models outperform literature-based ones due to better handling of nonlinearities and data preprocessing.

Long noncoding RNA MEG3 activates neuronal necroptosis in Alzheimer's disease

The paper shows that MEG3, a long noncoding RNA, induces necroptosis in human neurons exposed to amyloid pathology, mimicking AD features in a xenograft model.

Melanin Concentrating Hormone- and sleep-dependent synaptic downscaling is impaired in Alzheimer's Disease

This study identifies impaired MCH-system function in AD models and patients, disrupting synaptic downscaling and neuronal activity stability.

Single nucleus sequencing fails to detect microglial activation

The paper shows that single nucleus RNA-Seq fails to detect microglial activation genes in human brain samples compared to single cell RNA-Seq.

Impaired adult hippocampal neurogenesis in Alzheimer's disease is mediated by microRNA-132 deficiency and can be restored by microRNA-132 replacement

This study identifies miR-132 deficiency as a cause of impaired adult hippocampal neurogenesis in Alzheimer's disease and shows that restoring miR-132 levels can reverse these deficits and memory issues.

Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology

The paper identifies AD risk genes that influence microglia response to amyloid-β but not TAU pathology in mouse models.