Xiao Li

Developmental patterning of adipose tissue by abd-A and Abd-B homeotic genes in Drosophila melanogaster

The paper identifies transcriptional regulators of abd-A and Abd-B in Drosophila adipocytes, revealing a feedback circuit involving Lola, Piragua, Seven up, and Wnt signaling that controls adipose tissue patterning.

Metabolic control by the Bithorax Complex-Wnt signaling crosstalk in Drosophila

The paper identifies a genetic crosstalk between Bithorax Complex genes and Wnt signaling that drives regional metabolic differences in Drosophila adipocytes.

Distinct effects of CDK8 module subunits on cellular growth and proliferation in Drosophila

This study investigates the distinct roles of CDK8 module subunits in Drosophila, showing that Med12-Med13 disruption severely impacts ribosome biogenesis and growth, while CDK8-CycC affects cell-cycle progression.

DeDoc2 identifies and characterizes the hierarchy and dynamics of chromatin TAD-like domains in the single cells

DeDoc2 identifies and characterizes the dynamic hierarchy of TAD-like domains in single cells, showing their variability during the cell cycle and across human brain cortex cells.

SimulateCNVs: a novel software application for simulating CNVs in WES and WGS data

SimulateCNVs is a software tool that simulates copy number variations in whole exome and whole genome sequencing data, producing rearranged genomes, short reads, and BAM files.

The lysine demethylase dKDM2 is non-essential for viability, but regulates circadian rhythms in Drosophila

This study shows that dKDM2 is not essential for Drosophila viability but regulates circadian rhythms, with loss-of-function mutants showing arrhythmic behavior and overexpression causing shorter periods.

The 3D genome organization of Drosophila melanogaster through data integration

This paper integrates Hi-C and lamina-DamID data to compute 3D genome structures for Drosophila melanogaster, revealing structural features and functional insights.