Jian‐Quan Ni

FOCUS-3D segments cells in 3D fluorescence microscopy data across species and tissues, revealing phases of notochord morphogenesis in zebrafish.

This study shows that uORFs in the Clock gene regulate circadian rhythm and sleep by modulating CLK protein translation in Drosophila.

This study identifies Cdk13's role in preventing H3K9me3-heterochromatin spreading, which causes congenital heart defects, and shows a compound can alleviate these defects in mice.

This study identifies CDK8-CycC's role in Drosophila wing vein patterning by interacting with the Dpp/TGF{beta} pathway and regulating Mad-dependent transcription.

The paper measures stop codon readthrough in Drosophila across development and tissues, finding it varies with age and tissue type, being highest in neurons.

The paper identifies Zn72D as a regulator of ADAR-mediated RNA editing in Drosophila neurons and shows its conservation in mammals.

The paper updates TRiP's RNAi and CRISPR fly stocks, presenting over 5,000 CRISPR-OE and -KO stocks for gene activation and knockout studies in Drosophila.

This study shows that dKDM2 is not essential for Drosophila viability but regulates circadian rhythms, with loss-of-function mutants showing arrhythmic behavior and overexpression causing shorter periods.

This paper introduces flySAM, a CRISPRa tool for Drosophila that improves effectiveness, scalability, and ease-of-use compared to existing methods.