Petri Tanska

A computational framework to model cartilage degeneration induced by mechanoinflammation and cytokine-driven inflammation in post-traumatic osteoarthritis

Pericellular Matrix Proteoglycan Content is Less Affected in The Mid-Zone Cartilage in Early Post-Traumatic Osteoarthritis

This study shows that proteoglycan loss is less severe in the pericellular matrix than in the extracellular matrix in the middle zone of cartilage early after ACLT in rabbits.

MMP release following cartilage injury leads to collagen loss in intact tissue - a computational study

This study develops a computational model to simulate collagen loss in cartilage after injury, showing that MMP release from damaged cells leads to significant collagen degradation.

Mechanical Drivers of Glycosaminoglycan Content Changes in Intact and Damaged Human Cartilage

This study develops a mechanoregulatory model to predict how mechanical loading affects glycosaminoglycan content in human cartilage, showing increased GAG production in damaged cartilage under physiological loading.

Time-dependent computational model of post-traumatic osteoarthritis to estimate how mechanoinflammatory mechanisms impact cartilage aggrecan content

The paper develops a computational model to estimate how mechanoinflammatory mechanisms affect cartilage aggrecan content over time following joint injury.

Mechanobiochemical finite element model to analyze impact-loading-induced cell damage, subsequent proteoglycan loss, and anti-oxidative treatment effects in articular cartilage

This paper develops a computational model to simulate impact-induced cartilage damage, oxidative stress, and NAC treatment effects, showing NAC reduces proteoglycan loss by mitigating cell death and enzymatic depletion.

Automated analysis of rabbit knee calcified cartilage morphology using micro-computed tomography and deep learning segmentation

The paper develops a deep learning segmentation method for analyzing calcified cartilage thickness using micro-CT and compares it to histology across rabbit knee regions.