Ilse Jonkers

This study investigates how Wnt signaling and α5β1 integrins interact to modulate mechanical responses in human cartilage, showing integrins mediate Wnt-driven changes in load responsiveness.

This study shows OA chondrocytes generate higher contractile forces in 3D degradable hydrogels compared to 2D, linked to increased protrusive activity and actomyosin engagement.

This study develops a mechanoregulatory model to predict how mechanical loading affects glycosaminoglycan content in human cartilage, showing increased GAG production in damaged cartilage under physiological loading.

This study uses predictive simulations to assess how musculoskeletal impairments affect gait in children with cerebral palsy, finding that these impairments explain up to 39% of kinematic deviations.

This study uses a rat model to assess joint and tissue mechanics in post-traumatic osteoarthritis, finding no increased mechanical loading in the medial compartment despite structural changes.

This study examines how mechanical loading affects cartilage mechanoresponsiveness in healthy and osteoarthritic human cartilage, finding that loading rescues the chondrogenic phenotype in OA despite Wnt activation.

This study examines how cortical stimulation affects reaching behavior in young and older adults, finding that premotor area stimulation has greater effects on movement amplitude and path deviation than motor cortex stimulation, with age-related changes in motor control flexibility.

This study shows that similar sensorimotor transformations control balance during standing and walking, using delayed feedback of center of mass kinematics.

This study examines age-related changes in three-dimensional reaching movements under normal gravity conditions, finding reduced vertical precision and increased co-contraction in older adults.