Rocío Castro-Viñuelas

This study investigates how Wnt signaling and α5β1 integrins interact to modulate mechanical responses in human cartilage, showing integrins mediate Wnt-driven changes in load responsiveness.

This study shows OA chondrocytes generate higher contractile forces in 3D degradable hydrogels compared to 2D, linked to increased protrusive activity and actomyosin engagement.

This study develops a mechanoregulatory model to predict how mechanical loading affects glycosaminoglycan content in human cartilage, showing increased GAG production in damaged cartilage under physiological loading.

This study examines how mechanical loading affects cartilage mechanoresponsiveness in healthy and osteoarthritic human cartilage, finding that loading rescues the chondrogenic phenotype in OA despite Wnt activation.