Alan Jay Grodzinsky

This study develops a computational model to simulate collagen loss in cartilage after injury, showing that MMP release from damaged cells leads to significant collagen degradation.

The paper develops a computational model to estimate how mechanoinflammatory mechanisms affect cartilage aggrecan content over time following joint injury.

This study investigates how PEGylated cationic PAMAM dendrimers interact with proteins in synovial fluid and how these interactions affect their uptake in cartilage and internalization by chondrocytes.

This paper develops a computational model to simulate impact-induced cartilage damage, oxidative stress, and NAC treatment effects, showing NAC reduces proteoglycan loss by mitigating cell death and enzymatic depletion.

This study identifies Creb5 as a transcription factor required for TGF-β and EGFR signaling to induce Prg4 expression in superficial zone articular chondrocytes.