Author

Miguel de Jesus

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-9706-7249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Hui LiuiD· 1 shared Jahan A. RahmaniD· 1 shared Justin R. CrossiD· 1 shared Madeline A. Hwee· 1 shared Morgan HuseiD· 1 shared PAT B. ZANZONICOiD· 1 shared Ruben Jose Jesus Faustino Ramos· 1 shared Santosha Adipudi VardhanaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Hui LiuORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

MEK-dependent bioenergetic demand drives terminal CD8+ T cell exhaustion

Tanya Mitra, Jahan A. Rahman, Madeline A. Hwee, Yan-Ting Chen, Ruben Jose Jesus Faustino Ramos, Hui Liu, Travis E. Hartman, Justin R. Cross, Miguel de Jesus, Morgan Huse, Valerie A. Longo, PAT B. ZANZONICO, Santosha Adipudi Vardhana

This study shows that MEK inhibition reduces mitochondrial dysfunction and terminal CD8+ T cell exhaustion by decreasing nutrient uptake and RNA polymerase II activity.

Immunity · Jul 13, 2026Peer-reviewedImmunology