Morgan Huse

This study shows that MEK inhibition reduces mitochondrial dysfunction and terminal CD8+ T cell exhaustion by decreasing nutrient uptake and RNA polymerase II activity.

This study shows that cutaneous inflammation accelerates the expansion of premalignant melanocytes with oncogenic mutations in a mouse model.

This study identifies an atypical EMT induced by TGF-β in lung adenocarcinoma metastatic progenitors that reduces biomechanical stiffness, enabling evasion of immune surveillance during dormancy.

This study shows HIV Nef induces a soft phenotype in infected CD4+ T cells, reducing their susceptibility to cytotoxic T lymphocyte killing through cytoskeletal remodeling and intrinsic heterogeneity.

This study shows that enhancing Fas/FasL signaling improves CAR-T cell bystander killing against antigen-negative tumor cells, reducing antigen escape and improving therapeutic outcomes.

This study shows how cancer cell stiffness, influenced by environmental rigidity, affects immune response and metastatic site selection in mice and patients.

This study shows that β2 integrins regulate macrophage phagocytosis based on cargo rigidity, acting as a mechanical checkpoint to control engulfment strategies.