Endika Haro

The paper uses synthetic enhancer engineering in mESCs to show that enhancer clusters increase transcriptionally productive enhancer-gene contacts through enhanced RNA Polymerase II pause release.

The paper shows that developmental genes and CTCF site clusters work together to enhance insulation of regulatory domains in mouse embryonic stem cells.

The paper shows that nail tissue, not dorsoventral polarity, is essential for digit tip regeneration, and identifies Lmx1b's role in this process through transcriptomic analysis.

The paper identifies two Lmx1b cis-regulatory modules critical for limb development and shows their disruption in NPS patients with normal coding sequence.

The paper shows that orphan CpG islands enhance the regulatory activity of poised enhancers and influence the responsiveness of target genes.