Sara Cruz-Molina

Dual role of ZIC2 during neural induction: from pioneer transcription factor to enhancer activator

This study investigates ZIC2's role in neural development, showing it acts as a pioneer transcription factor during pluripotency exit and an enhancer activator during neural induction.

The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo

The paper shows that poised enhancers' chromatin and 3D features are conserved in vivo in mouse and chicken embryos, and they play essential roles in developmental gene induction.

Orphan CpG islands boost the regulatory activity of poisedenhancers and dictate the responsiveness of their target genes

The paper shows that orphan CpG islands enhance the regulatory activity of poised enhancers and influence the responsiveness of target genes.