The transcription factor OCT6 promotes the dissolution of the naive pluripotent state by repressing Nanog and activating a formative state gene regulatory network.
Ariel Waisman, Federico Sevlever, Denisse Saulnier, Marcos Gabriel Francia, Antonella Lombardi, Celeste Biani, María Belén Palma, Agustina Scarafía, Joaquín Smucler, Guadalupe Amín, Alejandro La Greca, Lucia Natalia Moro, Gustavo Emilio Sevlever, Alejandra Guberman, Santiago Miriuka
This paper identifies OCT6 as a key transcription factor promoting the transition from naive to formative pluripotency by repressing Nanog and activating formative gene regulatory networks in mouse embryonic stem cells.
bioRxiv · Jul 13, 2023 · PreprintDevelopmental Biology