Joaquín Smucler

LATEER is a low-cost, open-source platform for electrical stimulation and TEER measurement in human cardiomyocytes, validated with human pluripotent stem cell-derived cardiomyocytes and mesenchymal stem cells.

This study shows that increasing SPARC expression in mesenchymal stem cells enhances their secretome's ability to promote skin regeneration and wound healing.

The paper shows that WNT ON/OFF differentiation generates immature LV cardiomyocytes, which can be matured via metabolic maturation to achieve high-purity LV CMs.

The paper identifies SHEN-LONG, a cardiac regulatory locus, and shows it regulates NKX2-5 expression in iPSC-derived cardiomyocytes through a super-enhancer, with long-range effects on gene expression.

This paper identifies OCT6 as a key transcription factor promoting the transition from naive to formative pluripotency by repressing Nanog and activating formative gene regulatory networks in mouse embryonic stem cells.