Author

Alejandra Guberman

Consejo Nacional de Investigaciones Científicas y TécnicasORCID 0000-0002-4291-6741Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Agustina Scarafía· 2 shared Ariel WaismaniD· 2 shared Denisse Saulnier· 2 shared Guadalupe AmíniD· 2 shared Gustavo Emilio SevleveriD· 2 shared Joaquín SmucleriD· 2 shared Lucia Natalia MoroiD· 2 shared Santiago MiriukaiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersDevelopmental Biology

Agustina Scarafía

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Metabolic Maturation Unveils Left Ventricular Identity in WNT ON/OFF Human Pluripotent Stem Cell-Derived Cardiomyocytes

Joaquín Smucler, Julia Halek, Denisse Saulnier, Sheila Lucía Castañeda, Agustina Scarafía, Guadalupe Amín, Alejandra Guberman, Gustavo Emilio Sevlever, Santiago Miriuka, Lucia Natalia Moro, Ariel Waisman

The paper shows that WNT ON/OFF differentiation generates immature LV cardiomyocytes, which can be matured via metabolic maturation to achieve high-purity LV CMs.

bioRxiv · Dec 30, 2025 · PreprintDevelopmental Biology

The transcription factor OCT6 promotes the dissolution of the naive pluripotent state by repressing Nanog and activating a formative state gene regulatory network.

Ariel Waisman, Federico Sevlever, Denisse Saulnier, Marcos Gabriel Francia, Antonella Lombardi, Celeste Biani, María Belén Palma, Agustina Scarafía, Joaquín Smucler, Guadalupe Amín, Alejandro La Greca, Lucia Natalia Moro, Gustavo Emilio Sevlever, Alejandra Guberman, Santiago Miriuka

This paper identifies OCT6 as a key transcription factor promoting the transition from naive to formative pluripotency by repressing Nanog and activating formative gene regulatory networks in mouse embryonic stem cells.

bioRxiv · Jul 13, 2023 · PreprintDevelopmental Biology