Ariel Waisman

The paper shows that WNT ON/OFF differentiation generates immature LV cardiomyocytes, which can be matured via metabolic maturation to achieve high-purity LV CMs.

The paper identifies SHEN-LONG, a cardiac regulatory locus, and shows it regulates NKX2-5 expression in iPSC-derived cardiomyocytes through a super-enhancer, with long-range effects on gene expression.

This paper identifies OCT6 as a key transcription factor promoting the transition from naive to formative pluripotency by repressing Nanog and activating formative gene regulatory networks in mouse embryonic stem cells.

The paper applies Cellpose and a new ImageJ plugin to automatically and accurately segment myofibers in murine skeletal muscle, enabling unbiased quantification across different staining and fixation conditions.

The paper identifies piRNA expression during cardiac differentiation of human pluripotent stem cells and suggests their potential role in gene regulation during cardiomyocyte development.