Alejandro La Greca

Modulating SPARC Expression in Mesenchymal Stem Cells Improves Secretome-Mediated Skin Regeneration and Wound Repair

This study shows that increasing SPARC expression in mesenchymal stem cells enhances their secretome's ability to promote skin regeneration and wound healing.

Comparative cistromic analysis reveals a shift in tamoxifen-associated endometrial tumor ERα binding toward sites less frequently shared by progesterone receptors

The paper compares ERα cistromes in endometrial tumors from tamoxifen users and non-users to ERα and PR cistromes in Ishikawa cells, finding shifts in ERα binding patterns associated with tamoxifen exposure.

SHEN-LONG, a novel cardiac regulatory locus, regulates cardiac master transcription factor NKX2-5 in pluripotent stem cell derived cardiomyocytes

The paper identifies SHEN-LONG, a cardiac regulatory locus, and shows it regulates NKX2-5 expression in iPSC-derived cardiomyocytes through a super-enhancer, with long-range effects on gene expression.

The transcription factor OCT6 promotes the dissolution of the naive pluripotent state by repressing Nanog and activating a formative state gene regulatory network.

This paper identifies OCT6 as a key transcription factor promoting the transition from naive to formative pluripotency by repressing Nanog and activating formative gene regulatory networks in mouse embryonic stem cells.

Higher-order chromatin organization defines Progesterone Receptor and PAX2 binding to regulate estradiol-primed endometrial cancer gene expression

The paper identifies progestin control regions (PgCRs) where PR and PAX2 bind to regulate gene expression in endometrial cancer cells.

Analysis of the expression of PIWI-interacting RNAs during cardiac differentiation of human pluripotent stem cells

The paper identifies piRNA expression during cardiac differentiation of human pluripotent stem cells and suggests their potential role in gene regulation during cardiomyocyte development.