Gustavo Emilio Sevlever

Modulating SPARC Expression in Mesenchymal Stem Cells Improves Secretome-Mediated Skin Regeneration and Wound Repair

This study shows that increasing SPARC expression in mesenchymal stem cells enhances their secretome's ability to promote skin regeneration and wound healing.

Metabolic Maturation Unveils Left Ventricular Identity in WNT ON/OFF Human Pluripotent Stem Cell-Derived Cardiomyocytes

The paper shows that WNT ON/OFF differentiation generates immature LV cardiomyocytes, which can be matured via metabolic maturation to achieve high-purity LV CMs.

SHEN-LONG, a novel cardiac regulatory locus, regulates cardiac master transcription factor NKX2-5 in pluripotent stem cell derived cardiomyocytes

The paper identifies SHEN-LONG, a cardiac regulatory locus, and shows it regulates NKX2-5 expression in iPSC-derived cardiomyocytes through a super-enhancer, with long-range effects on gene expression.

Identification of microRNAs regulated by E2F transcription factors in human pluripotent stem cells

The paper identifies microRNAs regulated by E2F transcription factors in human pluripotent stem cells through RNA-seq and RT-qPCR, revealing their potential roles in cell cycle and differentiation.

The transcription factor OCT6 promotes the dissolution of the naive pluripotent state by repressing Nanog and activating a formative state gene regulatory network.

This paper identifies OCT6 as a key transcription factor promoting the transition from naive to formative pluripotency by repressing Nanog and activating formative gene regulatory networks in mouse embryonic stem cells.

Analysis of the expression of PIWI-interacting RNAs during cardiac differentiation of human pluripotent stem cells

The paper identifies piRNA expression during cardiac differentiation of human pluripotent stem cells and suggests their potential role in gene regulation during cardiomyocyte development.