Santiago Miriuka

This study shows that increasing SPARC expression in mesenchymal stem cells enhances their secretome's ability to promote skin regeneration and wound healing.

The paper shows that WNT ON/OFF differentiation generates immature LV cardiomyocytes, which can be matured via metabolic maturation to achieve high-purity LV CMs.

The paper identifies SHEN-LONG, a cardiac regulatory locus, and shows it regulates NKX2-5 expression in iPSC-derived cardiomyocytes through a super-enhancer, with long-range effects on gene expression.

This paper identifies OCT6 as a key transcription factor promoting the transition from naive to formative pluripotency by repressing Nanog and activating formative gene regulatory networks in mouse embryonic stem cells.

The paper identifies piRNA expression during cardiac differentiation of human pluripotent stem cells and suggests their potential role in gene regulation during cardiomyocyte development.