Jaroslaw Jacak

Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles

Bactericidal Membrane Attack Complex formation initiates at the new pole of E. coli

The paper tracks MAC pore localization on E. coli and finds that MAC deposition starts at the new bacterial pole, leading to inner membrane damage and halting division.

Hybrid MPL Scaffolds with Nanoscale Mechanobiology for Bone-on-Chip

This paper introduces a hybrid scaffold for bone-on-chip systems that mimics bone stiffness and enables single-cell studies, showing enhanced osteogenic marker expression through bioactivity and geometry.

3D Multiphoton Nanolithography with Bioresorbable Amino Acid-Based Resins

This paper demonstrates the use of amino acid-based resins in 3D multiphoton lithography to create sub-100 nm features with controlled hydrophobicity and mechanical properties.

Snorkel-tag Based Affinity Chromatography for Recombinant Extracellular Vesicle Purification

This paper introduces a Snorkel-tag system for affinity purification of extracellular vesicles using CD81 fused with tags and transmembrane domains, enabling non-destructive isolation and future applications in tracing and analyzing EVs.

Comprehensive label-free characterization of extracellular vesicles and their surface proteins

This study establishes quartz crystal microbalance (QCM) as a label-free method to characterize extracellular vesicles and their surface proteins, enabling improved quality control of EV-based therapeutics.

SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema

This study compares extracellular miRNA profiles in lipedema and healthy adipose tissue, finding that sEV miRNAs are differentially regulated in lipedema.