Author

Alka Saxena

Guy's and St Thomas' NHS Foundation TrustORCID 0000-0001-5683-0618Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:imaging· 2 Approach:statistical model· 2

Frequent Co-Authors

Gareth BalliD· 3 shared Anne-Laure SchangiD· 2 shared Anthony David EdwardsiD· 2 shared Bobbi FleissiD· 2 shared Juliette Van SteenwinckeliD· 2 shared Michelle L. KrishnaniD· 2 shared Pierre GressensiD· 2 shared Tifenn Le Charpentier· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Gareth BallORCID

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4 papers

Recent·Most cited

GenomicsbioRxivPreprintAug 21, 2023

Metastable Intermediates Identified in Epithelial to Mesenchymal Transition are Regulated by G-Quadruplex DNA Structures

Jessica J. King, Cameron W. Evans, Ulrich D. Kadolsky…·Nicole M. Smith

The paper introduces a new multiplexed single-cell sequencing method to identify metastable cell states during EMT and shows G-quadruplex DNA stabilization can inhibit EMT.

3 citations

humanscRNA-seq

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NeurosciencebioRxivPreprintJun 12, 2018

Genes associated with neuropsychiatric disease increase vulnerability to abnormal deep grey matter development

Harriet Cullen, Michelle L. Krishnan, Saskia Selzam…·Anthony David Edwards

The paper finds that genetic risk for neuropsychiatric diseases is linked to reduced deep grey matter volume in preterm infants, suggesting a mechanism for how early adversity interacts with genetic vulnerability.

1 citation

humanimaging

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ImmunologybioRxivPreprintMay 31, 2018

Loss of the Wnt/β-catenin pathway in microglia of the developing brain drives pro-inflammatory activation leading to white matter injury

Juliette Van Steenwinckel, Anne-Laure Schang, Michelle L Krishnan…·Pierre Gressens

The paper shows that reduced Wnt/β-catenin signaling in microglia of the developing brain causes pro-inflammatory activation and white matter injury, and that restoring this pathway can prevent these effects.

DOI 10.1101/334359

humanbulk RNA-seq

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GenomicsNature CommunicationsPeer-reviewedAug 30, 2017

Integrative genomics study of microglial transcriptome reveals effect of DLG4 (PSD95) on white matter in preterm infants.

Michelle L. Krishnan, Juliette Van Steenwinckel, Anne‐Laure Schang…·Pierre Gressèns

This paper identifies DLG4 (PSD95) expression in microglia and links genetic variation in DLG4 to white matter structure in preterm infants.

105 citationstop 1%

mousehuman

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