This study investigates working memory dysfunction in multiple sclerosis using continuous reproduction paradigms, finding increased recall error and decreased precision, and identifying decoding imprecision and swap error as key factors.

eLife · Jul 27, 2023Peer-reviewedNeuroscience

Ermin deficiency as an inside-out model of inflammatory dysmyelination

Amin Ziaei, Marta Garcia‐Miralles, Carola I. Radulescu, Harwin Sidik, Aymeric Silvin, Han‐Gyu Bae, Carine Bonnard, Nur Amirah Binte Mohammad Yusof, Costanza Ferrari Bardile, Liang Juin Tan, Alvin Yu Jin Ng, Sumanty Tohari, Leila Dehghani, Lily Henry, Xin Yi Yeo, , Mahmoud A. Pouladi

This study shows that Ermin deficiency causes myelin abnormalities and inflammation, leading to neurological deficits and increased susceptibility to demyelination, suggesting it as an 'inside-out' model for inflammatory dysmyelination.

Brain Pathology · Mar 13, 2022Peer-reviewedNeuroscience

Immunotherapy prevents long-term disability in relapsing multiple sclerosis over 15 years

Tomáš Kalinčík, Sifat Sharmin, Charles Benjamin Malpas, Tim D. Spelman, Dana Horáková, Eva Havrdová, María Trojano, Guillermo Izquierdo, Alessandra Lugaresi, Alexandre Prat, Marc Girard, Pierre Duquette, Pierre Grammond, Vilija Jokubaitis, Anneke van der Walt, , on behalf of the MSBase Study group

This study shows that immunotherapy reduces disability and relapses in relapsing multiple sclerosis over 15 years.

bioRxiv · Aug 23, 2019 · PreprintNeuroscience