Carola I. Radulescu

The paper develops a spatial averaging framework to analyze glial subcellular specialization in spatial transcriptomics data from mouse and human brain tissue, revealing differential transcriptomic responses between glial soma and processes in health and disease.

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

This study shows that Ermin deficiency causes myelin abnormalities and inflammation, leading to neurological deficits and increased susceptibility to demyelination, suggesting it as an 'inside-out' model for inflammatory dysmyelination.

The paper identifies molecular signatures and neurodevelopmental abnormalities in FMRP-deficient neurons derived from isogenic FMR1 knockout human embryonic stem cells.

The paper investigates how microbiota affects myelination and white matter plasticity in a Huntington disease mouse model, finding altered myelin thickness and oligodendrocyte numbers in germ-free conditions.