Author

Prashant Khandagale

National Institutes of HealthORCID 0000-0002-9751-2189Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

Daiki TaniyamaiD· 2 shared Yves G. PommieriD· 2 shared Allison L WelteriD· 1 shared Doureradjou PeroumaliD· 1 shared Liton Kumar SahaiD· 1 shared Manohar M. KodavatiiD· 1 shared Narottam AcharyaiD· 1 shared Shar-yin Naomi HuangiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

Daiki TaniyamaORCID

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3 papers

Recent·Most cited

SLFN11 puts the brakes on Alternative lengthening of telomeres

Prashant Khandagale, Allison L Welter, Shar-yin Naomi Huang, Daiki Taniyama, Yuichi Machida, Yves G. Pommier

This study identifies SLFN11 as a suppressor of the ALT telomere maintenance pathway, showing its re-expression reduces ALT activity in cancer cells.

bioRxiv · Dec 11, 2025 · PreprintCell Biology

Topoisomerase 3A (TOP3A) Dependent Alternative Lengthening of Telomeres (ALT)

Prashant Khandagale, Yilun Sun, Daiki Taniyama, Sourav Taru Saha, Liton Kumar Saha, Yves G. Pommier

This study identifies TOP3A's role in ALT telomere maintenance, showing its enrichment at ALT telomeres and its impact on TERRA and TERF2 stability.

Cell Reports · Jul 30, 2025Peer-reviewedCell Biology

Human DNA polymerase delta is a pentameric complex with dimeric p12 subunit: Implications in enzyme architecture and PCNA interaction

Prashant Khandagale, Doureradjou Peroumal, Manohar M. Kodavati, Narottam Acharya

Life Science Alliance · Mar 18, 2019Peer-reviewedBiochemistry