Author

Shar-Yin Naomi Huang

National Institutes of HealthORCID 0000-0002-4772-428XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:variant effect prediction· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Yves G. PommieriD· 3 shared Adrian M. BarisiD· 1 shared Allison L WelteriD· 1 shared Andrew SymesiD· 1 shared Aneal KhaniD· 1 shared Bhushan L. ThakuriD· 1 shared Christophe E. RedoniD· 1 shared Daiki TaniyamaiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

Yves G. PommierORCID

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3 papers

Recent·Most cited

SLFN11 puts the brakes on Alternative lengthening of telomeres

Prashant Khandagale, Allison L Welter, Shar-yin Naomi Huang, Daiki Taniyama, Yuichi Machida, Yves G. Pommier

This study identifies SLFN11 as a suppressor of the ALT telomere maintenance pathway, showing its re-expression reduces ALT activity in cancer cells.

bioRxiv · Dec 11, 2025 · PreprintCell Biology

Functional characterization of two variants in the mitochondrial topoisomerase gene TOP1MT that impact regulation of the mitochondrial genome

Iman Al Khatib, Jingti Deng, Andrew Symes, Marina Kerr, Hongliang Zhang, Shar-Yin Naomi Huang, Yves G. Pommier, Aneal Khan, Timothy E. Shutt

The paper characterizes two TOP1MT variants in a patient with hypertrophic cardiomyopathy, showing both impair mitochondrial functions but affect different aspects of mtDNA regulation.

Journal of Biological Chemistry · Aug 24, 2022Peer-reviewedMolecular Biology

BAMscale: quantification of DNA sequencing peaks and generation of scaled coverage tracks

Lőrinc Sándor Pongor, Jacob Gross, Roberto Vera Alvarez, Junko Murai, Sang‐Min Jang, Hongliang Zhang, Christophe E. Redon, Haiqing Fu, Shar-Yin Naomi Huang, Bhushan L. Thakur, Adrian M. Baris, Leonardo Mariño‐Ramírez, David Landsman, Mirit I. Aladjem, Yves G. Pommier

BAMscale processes DNA sequencing datasets to generate normalized peak scores and scaled coverage tracks for visualization.

Epigenetics & Chromatin · Apr 22, 2020Peer-reviewedBioinformatics