Author

Yogen Saunthararajah

Cleveland ClinicORCID 0000-0002-9757-1031Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Babal Kant JhaiD· 2 shared Xiaorong GuiD· 2 shared Arda DurmaziD· 1 shared Caroline SchuergeriD· 1 shared Daniel J. LindneriD· 1 shared Jaroslaw P. MaciejewskiiD· 1 shared Kwok Peng NgiD· 1 shared Lisa Cardone· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Babal Kant JhaORCID

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2 papers

Recent·Most cited

Urothelial-lineage master transcription factor hub proteomics shows mechanisms impeding urothelial cancer cell differentiation

Caroline Schuerger, Sudipta Biswas, Kwok Peng Ng, Lisa Cardone, Xiaorong Gu, Shinjini Ganguly, Rita Tohmé, Arda Durmaz, Maximilian Stich, Daniel J. Lindner, Babal Kant Jha, Omar Y. Mian, Yogen Saunthararajah

The paper identifies CoA and CoR dysregulation in urothelial cancer cells and shows that CoR inhibition can restore differentiation.

bioRxiv · Aug 17, 2026 · PreprintCancer Biology

FLT3-ITD signals for CEBPA and p53 proteolysis by the ubiquitin-proteosome pathway

Xiaorong Gu, Sudipta Biswas, Zeinab Albadry M. Zahran, Songa Bae, Ramesh Balusu, Jaroslaw P. Maciejewski, Babal Kant Jha, Yogen Saunthararajah

This study shows FLT3-ITD promotes CEBPA and p53 proteolysis via the ubiquitin-proteosome pathway, blocking differentiation and apoptosis, and suggests UPP-inhibitors as therapeutic options.

bioRxiv · Jul 15, 2026 · PreprintCancer Biology