Author

Babal Kant Jha

Cleveland ClinicORCID 0000-0002-7660-5255Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Xiaorong GuiD· 2 shared Yogen SaunthararajahiD· 2 shared Arda DurmaziD· 1 shared Belinda B. WillardiD· 1 shared Caroline SchuergeriD· 1 shared Daniel J. LindneriD· 1 shared Dongmei ZhangiD· 1 shared Jan Joseph MelenhorstiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Xiaorong GuORCID

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3 papers

Recent·Most cited

MCL1 may not mediate chemoresistance

Kylin A. Emhoff, Kunho Chung, Dongmei Zhang, Belinda B. Willard, Timothy An-thy Chan, Babal Kant Jha, Shaun R. Stauffer, Jesse A. Coker, Jan Joseph Melenhorst

This study challenges the role of MCL1 in chemoresistance by showing no evidence of nuclear accumulation or DNA repair interactions in live cancer cells.

Cancer Research Communications · Oct 29, 2026Peer-reviewedCell Biology

Urothelial-lineage master transcription factor hub proteomics shows mechanisms impeding urothelial cancer cell differentiation

Caroline Schuerger, Sudipta Biswas, Kwok Peng Ng, Lisa Cardone, Xiaorong Gu, Shinjini Ganguly, Rita Tohmé, Arda Durmaz, Maximilian Stich, Daniel J. Lindner, Babal Kant Jha, Omar Y. Mian, Yogen Saunthararajah

The paper identifies CoA and CoR dysregulation in urothelial cancer cells and shows that CoR inhibition can restore differentiation.

bioRxiv · Aug 17, 2026 · PreprintCancer Biology

FLT3-ITD signals for CEBPA and p53 proteolysis by the ubiquitin-proteosome pathway

Xiaorong Gu, Sudipta Biswas, Zeinab Albadry M. Zahran, Songa Bae, Ramesh Balusu, Jaroslaw P. Maciejewski, Babal Kant Jha, Yogen Saunthararajah

This study shows FLT3-ITD promotes CEBPA and p53 proteolysis via the ubiquitin-proteosome pathway, blocking differentiation and apoptosis, and suggests UPP-inhibitors as therapeutic options.

bioRxiv · Jul 15, 2026 · PreprintCancer Biology