A striosomal accumbens pathway drives compulsive seeking behaviors through an aversive Esr1+ hypothalamic-habenula circuit.
Thomas Contesse, Buse Yel Bektash, Marta Graziano, Chiara Forastieri, Alessandro Contestabile, Salomé Hahne, Felix Jung, Ifigeneia Nikolakopoulou, Xiao Cao, Vasiliki Skara, Ioannis Mantas, Sarantis Giatrellis, Marie Carlén, Rickard Sandberg, Daniela Calvigioni, Konstantinos Meletis
The paper identifies a striosomal ACB projection to the Esr1+ LHA-LHb pathway that drives compulsive seeking behaviors through aversive signaling.
bioRxiv · Oct 11, 2024 · PreprintNeuroscience