Sarantis Giatrellis

SIMPlex generates matched spatial and single-nucleus transcriptomic profiles from the same tissue section to resolve cell states with spatial signatures in mouse and human cancer tissues.

This study uses in utero lentiviral transduction to resolve clonal relationships and gene functions in developing mouse gut lineages, revealing distinct developmental patterns in mesenchyme and enteric nervous system.

The paper identifies a striosomal ACB projection to the Esr1+ LHA-LHb pathway that drives compulsive seeking behaviors through aversive signaling.

This study validates SNP-based demultiplexing for pooled scRNA-seq data across multiple non-human species, showing accurate demultiplexing with only transcriptome data and no prior genetic reference.