De Novo Design, Directed Evolution and Computational Study of Heme-Binding Helical Bundle Protein Catalysts for Biocatalytic Enantioselective Ge-H Insertion
Wei Huang, Gessica M. Adornato, Maggie Horst, Turki M. Alturaifi, Kai-Peng Hou, Peng Liu, William F. DeGrado, Yang Yang
This paper designs and evolves de novo helical bundle proteins to catalyze enantioselective Ge-H insertion, showing improved efficiency and selectivity through computational analysis and directed evolution.
Journal of the American Chemical Society · Oct 22, 2025Peer-reviewedBiochemistry