Federico Comoglio

scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation

This study identifies molecular and immune mechanisms driving malignant transformation from inverted papilloma to sinonasal squamous cell carcinoma using multi-omics analyses.

In vivo CRISPR screening identifies NF1/RASA1/TP53 co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesis

This study identifies NF1/RASA1/TP53 co-mutations and MEK signaling as key drivers of sinonasal tumorigenesis through in vivo CRISPR screening and drug response testing.

Large-scale analysis of the integration of enhancer-enhancer signals by promoters

The paper tests how enhancer pairs combine to activate promoters in mouse cells, finding near-additive behavior with non-linear scaling depending on promoter strength.

Systematic analysis of intrinsic enhancer-promoter compatibility in the mouse genome.

The paper systematically analyzes enhancer-promoter compatibility in the mouse genome using high-throughput assays, finding significant promoter selectivity and diverse compatibility patterns.

Dissection of acute stimulus-inducible nucleosome remodeling in mammalian cells

The paper develops a framework to analyze nucleosome remodeling in response to stimuli and finds that remodeling preferentially affects poorly positioned nucleosomes at enhancers.

Systematic identification of human SNPs affecting regulatory element activity

The paper identifies over 30,000 SNPs affecting regulatory element activity using SuRE reporter technology, linking them to gene regulation and potential human traits.

Promoter-intrinsic and local chromatin features determine gene repression in lamina-associated domains

The paper shows that LADs create a repressive chromatin environment that affects promoter activity and transcription elongation, with variability in promoter sensitivity to LAD repression.

Thrombopoietin signaling to chromatin elicits rapid and pervasive epigenome remodeling within poised chromatin architectures

This study investigates how TPO signaling rapidly remodels the epigenome in HSPCs by altering cis-regulatory activity and chromatin architecture.