Halil I. Ciftci

Insights into Therapeutic Discovery Through the Kelch Domain Structure of Keap1 at Ambient Temperature

This study reports the structure of the dimeric Keap1 Kelch domain at ambient temperature and identifies a novel compound, CNN, as a potential lead for Keap1 inhibition.

Production, Purification, and Crystallization of Recombinant HER2 Tyrosine Kinase Domain (HER2-TKD) as a Platform for Structure-Based Drug Screening

This study produces and purifies soluble recombinant HER2-TKD for structural studies and drug screening.

Expression, Purification, and Crystallization of Recombinant Human ABL-1 Kinase for Structure-Based Drug Screening Applications

This paper describes the expression, purification, and crystallization of recombinant human ABL-1 kinase for structural analysis and drug screening in CML.

Structural Insights into the Dynamics of Water in SOD1 Catalysis and Drug Interactions

This study presents the crystal structure of human SOD1 and analyzes its structural dynamics and interactions with potential drug candidates for ALS treatment.

Structural Characterization of TRAF6 N-terminal for Therapeutic Uses

The paper presents the structure of TRAF6 N-terminal domain at 2.6 Å resolution, providing insights into its domain organization and zinc-binding, which are critical for its function and therapeutic targeting.