Author

Jessica Lynn Williams

Cleveland ClinicORCID 0000-0002-9801-9580Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Organism:mouse· 4 Approach:statistical model· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

Brandon C. SmithiD· 3 shared Maria L. HabeaniD· 2 shared Morgan W. Psenicka· 2 shared Rachel A. TinkeyiD· 2 shared Andrew Eagar· 1 shared Arshiya MariamiD· 1 shared Benjamin C. ShawiD· 1 shared Ernest Johnson Freeman· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersNeuroscience

Brandon C. SmithORCID

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5 papers

Recent·Most cited

The BHMT-TET1 axis regulates glycolytic metabolism in oligodendrocytes and increases myelin in the EAE mouse model of multiple sclerosis

Marwan Shalih Maraicar, Sarah Sternbach, Morgan W. Psenicka, Katherine Knies, Ethan Lesco, Najmah Al Ramel, Andrew Eagar, Steven H. Zeisel, Ernest Johnson Freeman, Robert Clements, Jessica Lynn Williams, Jennifer Ann McDonough

The paper shows that activating the BHMT-TET1 pathway enhances oligodendrocyte metabolism and myelin production in an MS mouse model.

bioRxiv · Jul 27, 2026 · PreprintNeuroscience

BATF2 is a regulator of interferon-gamma signaling in astrocytes during neuroinflammation

Rachel A. Tinkey, Brandon C. Smith, Maria L. Habean, Jessica Lynn Williams

The paper identifies BATF2 as a key suppressor of overactive immune signaling in astrocytes during neuroinflammation by regulating IRF1 and Caspase-1 expression.

Cell Reports · Mar 1, 2025Peer-reviewedNeuroscience

A novel PSMB8 isoform associated with multiple sclerosis lesions induces P-body formation

Benjamin C. Shaw, Jessica Lynn Williams

The paper identifies a novel PSMB8 isoform upregulated in MS white matter lesions that induces P-body formation and may contribute to impaired glial repair.

Frontiers in Cellular Neuroscience · May 15, 2024Peer-reviewedMolecular Biology

Astrocyte interferon-gamma signaling dampens inflammation during chronic central nervous system autoimmunity via PD-L1

Brandon C. Smith, Rachel A. Tinkey, Orion D. Brock, Arshiya Mariam, Maria L. Habean, Ranjan Dutta, Jessica Lynn Williams

This study shows astrocytic IFN-gamma signaling reduces inflammation in MS via PD-L1, suggesting therapeutic potential.

Journal of Neuroinflammation · Oct 12, 2023Peer-reviewedNeuroscience

Regional astrocyte interferon-γ signaling regulates immunoproteasome-mediated protection during chronic autoimmunity

Brandon C. Smith, Maksim Sinyuk, Julius E. Jenkins, Morgan W. Psenicka, Jessica Lynn Williams

This study shows that IFN-γ signaling in astrocytes promotes the immunoproteasome, reducing oxidative stress and protein damage in chronic MS, thereby protecting the CNS.

bioRxiv · Dec 23, 2019 · PreprintNeuroscience