Author

Jennifer Ann McDonough

Kent State UniversityORCID 0000-0001-9809-2289Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Organism:human· 1

Frequent Co-Authors

Ernest Johnson Freeman· 2 shared Sarah SternbachiD· 2 shared Amanda Riley· 1 shared Andrew Eagar· 1 shared Ansuman ChattopadhyayiD· 1 shared Edric Ma· 1 shared Ethan Lesco· 1 shared Franca CambiiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersNeuroscience

Ernest Johnson Freeman

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4 papers

Recent·Most cited

The BHMT-TET1 axis regulates glycolytic metabolism in oligodendrocytes and increases myelin in the EAE mouse model of multiple sclerosis

Marwan Shalih Maraicar, Sarah Sternbach, Morgan W. Psenicka, Katherine Knies, Ethan Lesco, Najmah Al Ramel, Andrew Eagar, Steven H. Zeisel, Ernest Johnson Freeman, Robert Clements, Jessica Lynn Williams, Jennifer Ann McDonough

The paper shows that activating the BHMT-TET1 pathway enhances oligodendrocyte metabolism and myelin production in an MS mouse model.

bioRxiv · Jul 27, 2026 · PreprintNeuroscience

Changes to Astrocyte-associated Protein Expression at Different Timepoints of Cuprizone Treatment

Lana Frankle, Amanda Riley, Riely Tomor, Hannah Lee, Kole Jarzembak, Olesia Benedict, Sarah Sternbach, John Shelestak, Jennifer Ann McDonough, Robert John Clements

The paper measures changes in astrocyte-associated protein expression at different timepoints during cuprizone treatment, finding non-linear increases in A1 and A2 markers.

bioRxiv · Apr 20, 2023 · PreprintNeuroscience

The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signaling

Sheng Zhang, Yan Wang, Xiaoqing Zhu, Lanying Song, Xinhua Zhan, Edric Ma, Jennifer Ann McDonough, Hui Qun Fu, Franca Cambi, Judith B. Grinspan, Fuzheng Guo

This study shows TCF7l2 promotes oligodendrocyte differentiation by repressing autocrine BMP4 signaling, which is dysregulated in multiple sclerosis.

Journal of Neuroscience · Jan 15, 2021Peer-reviewedNeuroscience

NAT8L mRNA oxidation is linked to neurodegeneration in multiple sclerosis

Prakash Kharel, Naveen Kumar Singhal, Nicole R. West, Joram Rana, Lindsey A. Smith, Ernest Johnson Freeman, Ansuman Chattopadhyay, Jennifer Ann McDonough, Soumitra Basu

The paper links NAT8L mRNA oxidation to reduced NAA levels and neurodegeneration in multiple sclerosis.

bioRxiv · Apr 19, 2020 · PreprintMolecular Biology