Author

Brandon C. Smith

Cleveland State UniversityORCID 0000-0003-0106-8819Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jessica Lynn WilliamsiD· 3 shared Maria L. HabeaniD· 2 shared Rachel A. TinkeyiD· 2 shared Arshiya MariamiD· 1 shared Julius E. Jenkins· 1 shared Maksim Sinyuk· 1 shared Morgan W. Psenicka· 1 shared Orion D. BrockiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Jessica Lynn WilliamsORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

NeuroscienceCell ReportsPeer-reviewedMar 1, 2025

BATF2 is a regulator of interferon-gamma signaling in astrocytes during neuroinflammation

Rachel A. Tinkey, Brandon C. Smith, Maria L. Habean, Jessica Lynn Williams

The paper identifies BATF2 as a key suppressor of overactive immune signaling in astrocytes during neuroinflammation by regulating IRF1 and Caspase-1 expression.

11 citations

humanmouse

𝕏 PostBluesky

NeuroscienceJournal of NeuroinflammationPeer-reviewedOct 12, 2023

Astrocyte interferon-gamma signaling dampens inflammation during chronic central nervous system autoimmunity via PD-L1

Brandon C. Smith, Rachel A. Tinkey, Orion D. Brock…·Jessica Lynn Williams

This study shows astrocytic IFN-gamma signaling reduces inflammation in MS via PD-L1, suggesting therapeutic potential.

28 citationstop 3%

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 23, 2019

Regional astrocyte interferon-γ signaling regulates immunoproteasome-mediated protection during chronic autoimmunity

Brandon C. Smith, Maksim Sinyuk, Julius E. Jenkins…·Jessica Lynn Williams

This study shows that IFN-γ signaling in astrocytes promotes the immunoproteasome, reducing oxidative stress and protein damage in chronic MS, thereby protecting the CNS.

DOI 10.1101/2019.12.23.887455

mouseproteomics

𝕏 PostBluesky