Author

Orion D. Brock

Cleveland ClinicORCID 0000-0003-3993-0216Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Arshiya MariamiD· 1 shared Brandon C. SmithiD· 1 shared Jessica Lynn WilliamsiD· 1 shared Jessica M. TilliD· 1 shared Maria L. HabeaniD· 1 shared Morgan J. EngelhartiD· 1 shared Philip P. AherniD· 1 shared Rachel A. TinkeyiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Arshiya MariamORCID

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2 papers

Recent·Most cited

ImmunologyThe Journal of ImmunologyPeer-reviewedMar 1, 2026

Strain-level antigen variation facilitates immune evasion in Bacteroides thetaiotaomicron

Robert W. P. Glowacki, Jessica M. Till, Orion D. Brock…·Philip P. Ahern

This study identifies strain-level antigen variation in Bacteroides thetaiotaomicron that enables immune evasion by CD4+ T cells, revealing a mechanism for strain discrimination in the microbiome.

1 citation

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceJournal of NeuroinflammationPeer-reviewedOct 12, 2023

Astrocyte interferon-gamma signaling dampens inflammation during chronic central nervous system autoimmunity via PD-L1

Brandon C. Smith, Rachel A. Tinkey, Orion D. Brock…·Jessica Lynn Williams

This study shows astrocytic IFN-gamma signaling reduces inflammation in MS via PD-L1, suggesting therapeutic potential.

28 citationstop 3%

mousebulk RNA-seq

𝕏 PostBluesky