Author

Shane M. Murphy

Broad InstituteORCID 0000-0002-9805-4909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:snRNA-seq· 2 Research Focus:eQTL / molecular QTL mapping· 1 Research Focus:gene regulatory network inference· 1 Assay:scATAC-seq· 1

Frequent Co-Authors

Alan C. MulleniD· 2 shared Angela R. ShihiD· 2 shared Cristin AubiniD· 2 shared Eliana T. EpsteiniD· 2 shared Jacques DeguineiD· 2 shared Liat Amir-Zilberstein· 2 shared Ramnik J. XavieriD· 2 shared Toni Marie DeloreyiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Alan C. MullenORCID

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Author profile →

3 papers

Recent·Most cited

Single-cell transcriptomics reveals the impact of sex and age in the healthy human liver

Raza Ur Rahman, Eliana T. Epstein, Shane M. Murphy, Liat Amir-Zilberstein, Cristin Aubin, Toni Marie Delorey, Hope Koene, Lilly Fernandes, Kenneth K. Tanabe, Motaz Qadan, Cristina R. Ferrone, David L. Berger, Angela R. Shih, Jacques Deguine, Alan C. Mullen

This study uses single-cell RNA sequencing to analyze how sex and age affect gene expression and cellular interactions in healthy human liver cells.

JHEP Reports · Feb 11, 2026Peer-reviewedCell Biology

Population-scale multiome immune cell atlas reveals complex disease drivers

Masahiro Kanai, Toni Marie Delorey, Jarno K. Honkanen, Rodosthenis S. Rodosthenous, Julianna Juvila, Shane M. Murphy, Isabella Teixeira-Soldano, Hee Seung Hwang, Juha M Karjalainen, Jussi Halonen, Georgia Panagiotaropoulou, Yuanxiang Zhang, Cristin Aubin, Eric Chen, Kosaku Nanki, , Ramnik J. Xavier

The paper uses population-scale single-nucleus ATAC-seq and RNA-seq to identify regulatory variants and their disease associations in immune cells.

medRxiv · Nov 25, 2025 · PreprintGenetic & Genomic Medicine

Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution

Brianna R. Watson, Biplab Paul, Raza‐Ur Rahman, Liat Amir-Zilberstein, Åsa Segerstolpe, Eliana T. Epstein, Shane M. Murphy, Ludwig Geistlinger, Tyrone Lee, Angela R. Shih, Jacques Deguine, Ramnik J. Xavier, Jeffrey R. Moffitt, Alan C. Mullen

The paper uses spatial transcriptomics to map cell types and their spatial organization in healthy and fibrotic human liver, identifying changes in hepatocyte populations during fibrosis.

Nature Communications · Jan 2, 2025Peer-reviewedGenomics