Brianna R. Watson

RNA-aware tissue preservation workflows for high-quality spatial transcriptomics

This paper introduces an RNA-aware preservation method, RIPIN, that improves spatial transcriptomics data quality by inhibiting RNase activity across human and mouse tissues.

Brain-immune interactions generate pathogen-specific sickness states

The paper investigates pathogen-specific sickness states by analyzing immune and neural responses across multiple scales in various inflammatory models.

Essentialome-Wide Multigenerational Imaging Reveals Mechanistic Origins of Cell Growth Laws

The paper uses multi-generational imaging to study essential genes in E. coli, revealing new mechanisms behind growth laws and identifying unknown gene functions.

Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution

The paper uses spatial transcriptomics to map cell types and their spatial organization in healthy and fibrotic human liver, identifying changes in hepatocyte populations during fibrosis.

Spatial and temporal profiling of the complement system uncovered novel functions of the alternative complement pathway in brain development

The paper uses spatial transcriptomics to study complement system development in the brain, revealing distinct roles of the classical and alternative pathways.

Understanding prefrontal cortex functions by decoding its molecular, cellular and circuit organization

This study maps the molecular, cellular, and circuit organization of the prefrontal cortex and identifies a cell type involved in chronic pain pathogenesis.