MicrobiologyNature CommunicationsPeer-reviewed
UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN
Pengcheng Wang, Ziqiao Wang, Fei Feng…·Rong Zhang
This study identifies UHRF1 as a host factor that restricts HCoV-229E infection by epigenetically silencing its receptor APN, with age-related UHRF1 decline linked to increased viral susceptibility.
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